Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents
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چکیده
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Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents
BACKGROUND Parkinson's disease is a neurodegenerative disorder associated with oxidative stress and glutathione depletion. The induction of cellular glutathione levels by exogenous molecules is a promising neuroprotective approach to limit the oxidative damage that characterizes Parkinson's disease pathophysiology. Dithiolethiones, a class of sulfur-containing heterocyclic molecules, are known ...
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ژورنال
عنوان ژورنال: Chemistry Central Journal
سال: 2016
ISSN: 1752-153X
DOI: 10.1186/s13065-016-0210-z